Changing meat with Quorn’s mycoprotein reduces cancer-causing chemical compounds within the intestines

Researchers from Northumbria College have discovered that swapping pink and processed meat for Quorn’s mycoprotein, a fungi-based meat various, results in a big discount in intestinal genotoxins – which might trigger bowel most cancers – and will increase wholesome intestine micro organism.

Their examine, revealed within the European Journal of Vitamin, explored for the primary time the consequences of changing a excessive pink and processed meat consumption with mycoprotein on the degrees of most cancers inflicting chemical compounds, generally known as genotoxins, discovered within the intestines, in addition to the impression on intestine well being.

The randomized medical trial adopted 20 wholesome male adults aged 18-50 and was break up into two distinct phases. The meat section noticed trialists devour 240g of pink and processed meat – together with beef steak, pork sausages and ham slices – every day for a two-week interval. For the mycoprotein section, they consumed the identical weight in fungi-derived mycoprotein equivalents over a separate two-week interval, with a ‘washout’ interval of 4 weeks between the 2 phases.

Evaluation of stool and urine samples from the mycoprotein section revealed that ranges of detected genotoxins like nitroso compounds (NOC) and p-cresol – chemical contaminants which were discovered to be potential most cancers threat markers – had been considerably decreased. Conversely, outcomes from the meat section confirmed that genotoxin ranges had risen, probably rising the long-term threat of bowel most cancers, which is also called colorectal most cancers. The distinction between the meat and mycoprotein phases was statistically important.

In addition to delivering important reductions in dangerous genotoxins, the mycoprotein weight loss program was additionally discovered to considerably enhance intestine well being, rising the abundance of protecting micro organism equivalent to Lactobacilli, Roseburia, and Akkermansia, that are related to providing safety towards chemically induced tumours, irritation and bowel most cancers.

In distinction, findings from the meat section revealed a rise in intestine micro organism linked with points equivalent to most cancers, cardiovascular illnesses, weight acquire and different unfavorable well being outcomes.

Epidemiological knowledge constantly associates pink and processed meat with an elevated threat of bowel most cancers, resulting in suggestions from each EATLancet and the Worldwide Company for Analysis on Most cancers (IARC) to scale back meat consumption.

Commenting on the findings, lead researcher Dr Daniel Commane, Affiliate Professor in Dietary Sciences at Northumbria College, stated:

“Bowel most cancers is the fourth most typical most cancers within the UK, with greater than 40,000 new circumstances every year³, and knowledge constantly associates pink and processed meat consumption with rising folks’s threat.

“As earlier research had recognized that causes for this enhanced threat embody the truth that meat will increase genotoxicity and, probably, reduces fiber consumption resulting from it generally displacing plant meals, we needed to discover the impression of switching meat for the fungi-based mycoprotein when it got here to bowel most cancers threat.

“The examine confirmed that this dietary change delivers a big discount in genotoxicity and a rise in useful intestine microbes. Our findings recommend due to this fact that this high-fiber protein supply supplies an excellent various to meat within the context of intestine well being and will assist to scale back long-term bowel most cancers threat.”

The trial was investigator blind, which means the researchers didn’t know which group had which weight loss program, and members had been screened for any gastrointestinal illnesses or use of medicine that may have an effect on their intestine/gut, together with different situations like coronary artery illness and diabetes. Individuals had been additionally requested to keep away from consuming every other meat or Quorn mycoprotein merchandise apart from the equipped examine meals, in addition to any further excessive protein, fibre or probiotic dietary supplements, throughout the trial.

This newest examine provides to the rising physique of proof that the nutritious protein supply that’s mycoprotein gives substantial well being advantages, defending towards a spread of illnesses and situations.

With official dietary recommendation encouraging everybody to devour much less meat to enhance the well being of individuals and our planet, options equivalent to Quorn’s mycoprotein, which has a superb diet profile, being excessive in protein and fiber, low in saturated fats and free from trans-fat and ldl cholesterol, is basically vital. Whereas many meat options are plant-based, mycoprotein is fungi-based which, rising proof suggests, brings a spread of further advantages to metabolic well being.”

Tim Finnigan, Scientific Advisor for Quorn Meals

Lecturers from Northumbria’s Vitamin and Meals Analysis Group are persevering with to research the impression of mycoprotein on intestine well being. Particularly, they’re concerned about understanding how the intestine makes use of fibres in mycoprotein, equivalent to chitin, beta glucan and mannan, and whether or not they would possibly assist prepare our immune methods or assist in reducing levels of cholesterol, for instance. The analysis staff additionally stated that additional research are wanted to have a look at the impression of mycoprotein on intestine well being in numerous participant teams, illness or well being states, and with different intestine well being outcomes.

This examine is the newest to show how Quorn’s mycoprotein delivers important well being advantages, together with urge for food regulation for these with weight problems and sort 2 diabetes, muscle progress and decreasing levels of cholesterol.


Journal reference:

Farsi, D.N., et al. (2023) Substituting meat for mycoprotein reduces genotoxicity and will increase the abundance of useful microbes within the intestine: Mycomeat, a randomised crossover management trial. European Journal of Vitamin.