Microneedle Bandage for Hemostatic Management

Scientists at Penn State have developed a microneedle bandage that may quickly cease bleeding. Uncontrolled bleeding following a traumatic damage is a significant reason behind demise within the younger, and growing new medical applied sciences that may quickly cease bleeding can be extremely helpful. This bandage incorporates an array of biodegradable and biocompatible microneedles made utilizing a gelatin methacryloyl biomaterial. The system additionally incorporates silicate nanoplatelets that give it its hemostatic properties, and the needle construction will increase the floor space for blood contact and helps to bind the bandage to the injured tissue.

Blood loss is a number one reason behind demise for People beneath the age of 46. If a traumatic damage happens, then stopping blood loss is the primary precedence. Blood loss from some accidents may be stopped by making use of a tourniquet, however this isn’t attainable in each state of affairs and for each damage. A ready-to-use, extremely efficient hemostatic bandage can be a very helpful element in first help kits or navy area kits as a first-line protection in opposition to these conditions.   

“Extreme bleeding is a severe problem for human well being,” mentioned Amir Sheikhi, a researcher concerned within the examine. “With hemorrhaging accidents, it’s usually the lack of blood — not the damage itself — that causes demise. There may be an unmet medical want for ready-to-use biomaterials that promote fast blood coagulation.” 

These researchers turned to microneedle arrays as a method to cease bleeding. Medgadget has reported on microneedle bandages earlier than, however sometimes they’re conceived as a method of drug or vaccine supply. On this paradigm, the microneedles act to considerably enhance the floor space of the bandage that contacts the blood rising from the wound, and enhance the adhesion between the bandage and the wound, which additionally helps with wound closure.

Thus far, the researchers have examined the bandage in a rat liver bleeding mannequin, the place it confirmed spectacular efficacy and decreased bleeding by roughly 92% in contrast with an untreated management group. The bandages additionally outperformed a business hemostat in lowering bleeding.

In vitro, the engineered microneedle arrays decreased clotting time from 11.5 minutes to 1.3 minutes; and in a rat liver bleeding mannequin, they decreased bleeding by greater than 90%,” mentioned Sheikhi. “These 10 minutes might be the distinction between life and demise.”

Research in journal Bioactive Supplies: Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment

Through: Penn State